Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis

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Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis

OBJECTIVE In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation to glial activation in the same cohort of participants. METHODS Ten individuals with amyotrophic lateral sclerosis (ALS) and 10 matched healthy controls underwent brain imaging using integrated MR/PET and the radioligand [11C]-PBR28. Diagnosis history and clinical assessments including Upp...

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Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven mal...

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ژورنال

عنوان ژورنال: Neurology

سال: 2016

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0000000000003427